Xiaolong Tang

Sirt7 regulates circadian phase coherence of hepatic circadian clock via a body temperature/Hsp70-Sirt7-Cry1 axis

This study identifies a novel body temperature/Hsp70-Sirt7-Cry1 axis that maintains circadian phase coherence in mouse liver by regulating Sirt7 activity.

SIRT6 as a transcriptional coactivator of GATA4 prevents doxorubicin cardiotoxicity independently of its deacylase activity

This study identifies SIRT6 as a non-enzymatic coactivator of GATA4 that protects against doxorubicin-induced cardiotoxicity by enhancing GATA4 acetylation through recruitment of Tip60.

Boosting ATM Activity Promotes Longevity in Nematodes and Mice

The paper shows that boosting ATM activity with chloroquine extends lifespan in nematodes and mice by improving DNA repair and metabolic health.