Exposure to immune stimuli reprograms alveolar macrophages to acquire neutrophil-derived antimicrobial molecules to prevent staphylococcal pneumonia
Amit P. Sharma, Linda M. Heffernan, Venkatesh Mayandi, Seetharama D. S. Jois, William N. Beavers, Basel H. Abuaita
The paper shows that prior exposure to immune stimuli enhances protection against MRSA pneumonia by reprogramming alveolar macrophages to acquire neutrophil-derived antimicrobial enzymes.
bioRxiv · Dec 5, 2025 · PreprintImmunology