William N. Beavers

Efficient colonic colonization by Campylobacter jejuni requires the heme receptor ChuA

This study shows that the heme receptor ChuA is essential for Campylobacter jejuni to efficiently colonize the colon and cause inflammation.

Integrated Lipidomics and Nitro-Fatty Acid Profiling Link Adipose Redox Imbalance to Alzheimer's Disease-Related Neurovascular Injury

The paper investigates adipose lipid-redox imbalances in AD using multi-omics and imaging, finding that lipid modifications and redox markers correlate with neurovascular injury and amyloid pathology.

Exposure to immune stimuli reprograms alveolar macrophages to acquire neutrophil-derived antimicrobial molecules to prevent staphylococcal pneumonia

The paper shows that prior exposure to immune stimuli enhances protection against MRSA pneumonia by reprogramming alveolar macrophages to acquire neutrophil-derived antimicrobial enzymes.

FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis

This study identifies FapR as a regulator of HssRS-mediated heme homeostasis in B. anthracis, showing its role in maintaining membrane integrity and HssS localization.

Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses

This study shows that activating IRE1α in the lungs during MRSA infection worsens pneumonia by increasing inflammation and cell death, but blocking IRE1α improves survival and reduces lung damage.

Efficient gastrointestinal colonization by Campylobacter jejuni requires components of the ChuABCD heme transport system

This study shows that the ChuABCD heme transport system in Campylobacter jejuni is necessary for efficient colonization and pathogenicity, though not fully essential.