CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD
Anubhav Chakraborty, Meekha M. Varghese, Darren P. Wallace, Christopher J. Ward, Alan S.L. Yu
This study uses CRISPR activation to increase PKD1 expression in ADPKD models, reducing cyst formation and improving cellular features.
American Journal of Physiology-Renal Physiology · Sep 22, 2026Peer-reviewedMolecular Biology