Author

Christopher J. Ward

University of Kansas Medical CenterORCID 0000-0002-2507-9398Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Christopher J. Ward4 papers · University of Cambridge

Biology Disciplines

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Molecular Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Meekha M. VargheseiD· 2 shared Abeda JamadariD· 1 shared Alan S.L. YuiD· 1 shared Alejandra Vásquez‐LimetaiD· 1 shared Anubhav ChakrabortyiD· 1 shared Darren P. WallaceiD· 1 shared Ernesto Reyes-SancheziD· 1 shared Francisco J AltamiranoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Meekha M. VargheseORCID

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3 papers

Recent·Most cited

CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD

Anubhav Chakraborty, Meekha M. Varghese, Darren P. Wallace, Christopher J. Ward, Alan S.L. Yu

This study uses CRISPR activation to increase PKD1 expression in ADPKD models, reducing cyst formation and improving cellular features.

American Journal of Physiology-Renal Physiology · Sep 22, 2026Peer-reviewedMolecular Biology

Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in Cardiomyocytes

Matthew J. Fiedler, Alejandra Vásquez‐Limeta, Ernesto Reyes-Sanchez, Monserrat Reyes-Lozano, William M. Perez, Leah Carter, Christopher J. Ward, Francisco J Altamirano

This study shows that PC1-CT in cardiomyocytes activates PI3K-Akt-mTOR-S6K1-S6 signaling to enhance protein synthesis pathways without inducing canonical hypertrophy.

bioRxiv · Mar 24, 2026 · PreprintPhysiology

Circadian clock disruption and growth of kidney cysts in autosomal dominant polycystic kidney disease

Abeda Jamadar, Christopher J. Ward, Viji Remadevi, Meekha M. Varghese, Navjotsingh Pabla, Michelle L. Gumz, Reena Rao

This study shows that disrupting the circadian clock in kidney cells accelerates ADPKD progression by altering lipid metabolism.

Journal of the American Society of Nephrology · Oct 14, 2024Peer-reviewedMolecular Biology