Liping Wei

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

MosaicBase is a database of postzygotic mosaic variants in noncancer diseases and asymptomatic individuals, revealing distinct genomic features of disease-causing variants.

The paper profiles somatic L1Hs insertions in Rett patients and healthy controls, finding increased insertions in the brain and altered genomic patterns linked to MECP2 dysfunction.

The paper identifies and characterizes two types of postzygotic single-nucleotide mosaicisms in healthy individuals using whole-genome sequencing across multiple organs.