Author

Xianing Zheng

National Institute of Biological Sciences, BeijingORCID 0000-0002-3302-1241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Approach:benchmark study· 1

Frequent Co-Authors

Adam Yongxin YeiD· 3 shared August Yue HuangiD· 3 shared Liping WeiiD· 3 shared Qixi WuiD· 3 shared Xiaoxu YangiD· 3 shared Adrienne Niederriter Shami· 2 shared Gabriel L. ManskeiD· 2 shared Jun Z. LiiD· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersGenomics

Adam Yongxin YeORCID

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5 papers

Recent·Most cited

Tcf21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration

Yu-chi Shen, Adrienne Niederriter Shami, Lindsay Moritz, Hailey Larose, Gabriel L. Manske, Qianyi Ma, Xianing Zheng, Meena Sukhwani, Michael J. Czerwinski, Caleb Sultan, Haolin Chen, Stephen J. Gurczynski, Jason R. Spence, Kyle E. Orwig, Michelle D. Tallquist, , Saher Sue Hammoud

This study identifies Tcf21+ mesenchymal progenitors in mouse testis that contribute to somatic cell development, homeostasis, and regeneration.

Nature Communications · Jun 23, 2021Peer-reviewedDevelopmental Biology

Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis

Adrienne Niederriter Shami, Xianing Zheng, Sarah K. Munyoki, Qianyi Ma, Gabriel L. Manske, Christopher D. Green, Meena Sukhwani, Kyle E. Orwig, Jun Z. Li, Saher Sue Hammoud

The paper uses single-cell RNA sequencing to compare spermatogenesis in human, macaque, and mouse testes, identifying conserved and divergent molecular features across species.

Developmental Cell · Jun 5, 2020Peer-reviewedGenetics

MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Diseases and Asymptomatic Human Individuals

Xiaoxu Yang, Changhong Yang, Xianing Zheng, Luoxing Xiong, Yu‐Tian Tao, Meng Wang, Adam Yongxin Ye, Qixi Wu, Yanmei Dou, Junyu Luo, Liping Wei, August Yue Huang

MosaicBase is a database of postzygotic mosaic variants in noncancer diseases and asymptomatic individuals, revealing distinct genomic features of disease-causing variants.

Genomics Proteomics & Bioinformatics · Apr 1, 2020Peer-reviewedBioinformatics

Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

Boxun Zhao, Qixi Wu, Adam Yongxin Ye, Jing Guo, Xianing Zheng, Xiaoxu Yang, Linlin Yan, Qing‐Rong Liu, Thomas M. Hyde, Liping Wei, August Yue Huang

The paper profiles somatic L1Hs insertions in Rett patients and healthy controls, finding increased insertions in the brain and altered genomic patterns linked to MECP2 dysfunction.

PLoS Genetics · Apr 11, 2019Peer-reviewedGenomics

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs

August Yue Huang, Xiaoxu Yang, Sheng Wang, Xianing Zheng, Qixi Wu, Adam Yongxin Ye, Liping Wei

The paper identifies and characterizes two types of postzygotic single-nucleotide mosaicisms in healthy individuals using whole-genome sequencing across multiple organs.

PLoS Genetics · May 15, 2018Peer-reviewedGenomics