Mark A. Good

This study investigates the effects of the 5:2 diet on adult hippocampal neurogenesis and spatial memory in mice, finding no significant impact on neurogenesis or memory performance.

The paper phenotypes Dp1Tyb mice, a Down syndrome model, and identifies multiple DS-like traits including cognitive and physical abnormalities.

The paper identifies distinct hippocampal and prefrontal cortex circuit dysfunctions in DS mouse models linked to specific regions of human chromosome 21.