Identifying the Copper Coordination Environment Between Interacting Neurodegenerative Proteins: A New Approach Using Pulsed EPR with 14N/15N Isotopic Labelling
Amanda Smart, Kevin Singewald, Zikri Hasanbasri, R. David Britt, Glenn L. Millhauser
This paper uses pulsed EPR with 14N/15N isotopic labeling to characterize Cu2+ coordination between PrPC and Aβ, revealing how copper bridges these proteins in a ternary complex.
Journal of Biological Chemistry · Feb 13, 2025Peer-reviewedBiophysics