Glenn L. Millhauser

The paper identifies His176 as a key residue for copper coordination in the prion protein using sortase-mediated ligation and pulsed EPR, supported by AlphaFold 3 simulations.

This paper uses pulsed EPR with 14N/15N isotopic labeling to characterize Cu2+ coordination between PrPC and Aβ, revealing how copper bridges these proteins in a ternary complex.

This study shows that N-linked glycans on PrPC are essential for maintaining a non-toxic structure and suppressing neurotoxicity through intramolecular interactions.