BiochemistryJournal of the American Chemical SocietyPeer-reviewed
Protein Scaffolds Modulate the Electronic Structure of a Common Ketyl Radical Intermediate in Thiamine Pyrophos-phate-Dependent Radical Biocatalysis: Insights from EPR and ENDOR Spectroscopy
Guodong Rao, Zheng Zhang, Xin Liu…·Yang Yang
This study uses EPR and ENDOR spectroscopy along with DFT to show how protein scaffolds alter the electronic structure of a ketyl radical intermediate in TPP-dependent radical biocatalysis, affecting enzyme reactivity.
DOI 10.1021/jacs.6c16863