Author

Josef H. Vormoor

University Medical Center UtrechtORCID 0000-0002-1825-1890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Olaf T HeidenreichiD· 3 shared Mirjam E. BelderbosiD· 2 shared Alicia PerzolliiD· 1 shared Andrej LissatiD· 1 shared Anita T. van Oort· 1 shared Anja Krippner‐HeidenreichiD· 1 shared Bexultan KazybayiD· 1 shared Bianca F. GoemansiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

Olaf T HeidenreichORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 7, 2026

Spatial multi-omics reveals targetable immunosuppressive macrophage T-cell interactions in human AML bone marrow

Merel van der Meulen, Emma S. Pool, Alicia Perzolli…·Olaf T Heidenreich

This paper uses spatial multi-omics to identify immunosuppressive interactions between AML, macrophages, and T cells in bone marrow, highlighting the Galectin-9 - CD44/TIM-3 axis as a therapeutic target.

DOI 10.64898/2026.08.07.743431

humanspatial transcriptomics

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Cancer BiologyLeukemiaPeer-reviewedAug 15, 2025

Distinct Stromal Cell Populations Define the B-cell Acute Lymphoblastic Leukemia Microenvironment

Mauricio N. Ferrao Blanco, Bexultan Kazybay, Mirjam E. Belderbos…·Josef H. Vormoor

This study identifies distinct stromal cell populations in B-ALL bone marrow and shows their roles in supporting leukemic cell survival and chemoresistance.

12 citationstop 2%

humanscRNA-seq

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Cancer BiologybioRxivPreprintFeb 13, 2025

RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia

Polina K. Derevyanko, Laura E. Swart, L. Daniel Mata Casimiro…·Olaf T Heidenreich

This study shows that depletion of RUNX1::RUNX1T1 in AML cells reduces stemness and promotes differentiation into granulocytic and eosinophilic/mast cell-like populations.

DOI 10.1101/2025.02.13.637937

humanbulk RNA-seq

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