Mirjam E. Belderbos

This paper uses spatial multi-omics to identify immunosuppressive interactions between AML, macrophages, and T cells in bone marrow, highlighting the Galectin-9 - CD44/TIM-3 axis as a therapeutic target.

The paper generates a single-cell multi-omics atlas of pediatric bone marrow, revealing age-related shifts in lineage differentiation linked to stromal cell heterogeneity.

This study examines lymphocyte dynamics during chemotherapy in pediatric AML, finding preserved or increased lymphocytes alongside blast reduction, suggesting a potential window for BiTE therapy.

This study identifies distinct stromal cell populations in B-ALL bone marrow and shows their roles in supporting leukemic cell survival and chemoresistance.

The paper introduces PTATO, a bioinformatic workflow for detecting somatic mutations in single-cell WGS data using PTA, achieving high sensitivity for base substitutions and indels.