Siriruk Changrob

This study shows that CR3022-like antibodies can be evolved in vivo through vaccination to neutralize SARS-CoV-2 and related viruses by enhancing affinity and breadth.

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

This paper introduces a hybrid demultiplexing strategy that improves cell hashing accuracy and recovery without increasing experimental cost.