Author

Joshua J.C. McGrath

Weill Cornell MedicineORCID 0000-0002-9267-5501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Lei LiiD· 2 shared Patrick C. WilsoniD· 2 shared Siriruk ChangrobiD· 2 shared Yanbin FuiD· 2 shared Andrew T. CheniD· 1 shared Art MarzokiD· 1 shared Chloe A. TroxelliD· 1 shared G. Dewey WilbanksiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Lei LiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Senataxin is required for optimal class switch recombination to the immunoglobulin A isotype

Vithushan Surendran, Jonathan Mapletoft, Peter YF. Zeng, Julia Avolio, Sam Afkhami, Joshua J.C. McGrath, Andrew T. Chen, Art Marzok, Jann Catherine Ang, Kyle Amaral, Yona Tugg, Martin R. Stämpfli, Matthew S. Miller

This study shows that senataxin deficiency impairs class switch recombination to IgA in vitro, reduces IgA response to infection, and decreases IgA repertoire diversity in vivo.

bioRxiv · Sep 23, 2025 · PreprintImmunology

Mutability and hypermutation antagonize immunoglobulin codon optimality

Joshua J.C. McGrath, Juyeon Park, Chloe A. Troxell, Jordan C. Chervin, Lei Li, Johnathan R. Kent, Siriruk Changrob, Yanbin Fu, Min Huang, Nai‐Ying Zheng, G. Dewey Wilbanks, Sean A. Nelson, Jiayi Sun, Giorgio Inghirami, Maria Lucia L. Madariaga, , Patrick C. Wilson

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

Molecular Cell · Dec 20, 2024Peer-reviewedImmunology

A hybrid demultiplexing strategy that improves performance and robustness of cell hashing

Lei Li, Jiayi Sun, Yanbin Fu, Siriruk Changrob, Joshua J.C. McGrath, Patrick C. Wilson

This paper introduces a hybrid demultiplexing strategy that improves cell hashing accuracy and recovery without increasing experimental cost.

Briefings in Bioinformatics · May 23, 2024Peer-reviewedBioinformatics