Patrick C. Wilson

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

The paper characterizes antigenic differences in H15 influenza virus hemagglutinin by analyzing mAb binding and neutralization against ancestral and drifted strains.

This study shows that CR3022-like antibodies can be evolved in vivo through vaccination to neutralize SARS-CoV-2 and related viruses by enhancing affinity and breadth.

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

This paper introduces a hybrid demultiplexing strategy that improves cell hashing accuracy and recovery without increasing experimental cost.