Lei Li

BiNVaST improves cell typing across spatial transcriptomic platforms by generating synthetic data that preserves niche boundaries and integrates molecular and spatial information.

RSVrecon is a bioinformatics pipeline that enhances RSV surveillance by automating genotyping and reporting clinically important mutations, providing user-friendly results for clinical researchers.

This study shows that CR3022-like antibodies can be evolved in vivo through vaccination to neutralize SARS-CoV-2 and related viruses by enhancing affinity and breadth.

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

This paper introduces a hybrid demultiplexing strategy that improves cell hashing accuracy and recovery without increasing experimental cost.

This study develops DeepCSO, a deep-learning tool for predicting Cysteine S-sulphenylation sites across species, showing improved performance over existing methods.