In Vivo Evolution of Monoclonal Antibody CR3022 to Achieve Cross-Neutralization of SARS-CoV-2 and Implications for Vaccine Strategies Against SARS-Related Viruses
Yanbin Fu, Ziqi Feng, Steven A. Erickson, Peter Halfmann, Lei Li, Jordan C. Chervin, Chloe A. Troxell, Jiayi Sun, Atsuhiro Yasuhara, Siriruk Changrob, Min Huang, Nai‐Ying Zheng, Meng Yuan, Yoshihiro Kawaoka, Ian A. Wilson, Patrick C. Wilson
This study shows that CR3022-like antibodies can be evolved in vivo through vaccination to neutralize SARS-CoV-2 and related viruses by enhancing affinity and breadth.
bioRxiv · Aug 5, 2025 · PreprintImmunology