Translational control of AMPK activity in melanoma
Natália Vadovičová, Anna Lešková, Katerina Kozdonova, Karolina Smolkova, Barbora Valčíková, Filip Kafka, David Potěšil, Zbyněk Zdráhal, Ondřej Vacek, Ráchel Víchová, Karel Souček, Stjepan Uldrijan
This study shows eIF4F inhibition increases AMPK activity in BRAF-mutant melanoma cells by both reducing LKB1 and enhancing PP2A activity, suggesting new therapeutic strategies.
Cell Communication and Signaling · Apr 28, 2026Peer-reviewedCancer Biology