Zbyněk Zdráhal

This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.

This study shows eIF4F inhibition increases AMPK activity in BRAF-mutant melanoma cells by both reducing LKB1 and enhancing PP2A activity, suggesting new therapeutic strategies.

The paper identifies SMG7 and eIF4A as a regulatory module that controls P-body condensation and function of meiotic bodies in Arabidopsis.

This study shows that ammonium and alkylammonium counterions enhance RNA polymerization from 2,3-cyclic nucleotides under dry, geologically plausible conditions.

The paper identifies TRFL7 as a telomere-binding protein in Arabidopsis, showing it functions similarly to human TRF2 in telomere maintenance.

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

This study identifies PRICKLE3's role in stabilizing WNT/PCP complexes by inhibiting RNF43-mediated ubiquitination of VANGL1/2.

This study compares translational regulation in two Arabidopsis accessions during seed germination, identifying differences in mRNA abundance, RNA modifications, and protein expression.

The paper identifies RAI14, EPHA2, and PHACTR4 as essential components of the Wnt/PCP pathway in vertebrates through BioID and zebrafish loss-of-function studies.

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.

The paper identifies mTORC1 and 7mG-cap dependent translation as regulators of spatial positioning of blastomeres during the 8- to 16-cell transition in mouse embryos.

This study investigates the role of DDX21 in mouse preimplantation embryo development, showing its necessity for cell-fate specification and blastocyst formation through p38-MAPK regulation.

This study shows that p38-MAPK regulates PrE differentiation during mouse blastocyst maturation by controlling translation and rRNA processing through Mybpp1a.