Author

Filip Kafka

Masaryk UniversityORCID 0000-0002-9923-0732Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jan FričiD· 3 shared Veronika BosákováiD· 3 shared Ioanna PapatheodorouiD· 2 shared Marcela Hortová KohoutkováiD· 2 shared Anna Lešková· 1 shared Barbora ValčíkováiD· 1 shared Bo-Jun KeiD· 1 shared Bram VerstocktiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

Jan FričORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Translational control of AMPK activity in melanoma

Natália Vadovičová, Anna Lešková, Katerina Kozdonova, Karolina Smolkova, Barbora Valčíková, Filip Kafka, David Potěšil, Zbyněk Zdráhal, Ondřej Vacek, Ráchel Víchová, Karel Souček, Stjepan Uldrijan

This study shows eIF4F inhibition increases AMPK activity in BRAF-mutant melanoma cells by both reducing LKB1 and enhancing PP2A activity, suggesting new therapeutic strategies.

Cell Communication and Signaling · Apr 28, 2026Peer-reviewedCancer Biology

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

Sofia Morazzo, Soraia Fernandes, Marina Fortea, Helena Skálová, Daniel Pereira-Sousa, Marco Cassani, Kamila Vrzalová, Filip Kafka, Jan Vrbský, Mathilde Soulez, Sylvain Meloche, Ole Morten Seternes, Veronika Bosáková, Jaeyoung Shin, Jan Frič, , Giancarlo Forte

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

Frontiers in Oncology · Aug 27, 2025Peer-reviewedCancer Biology

Serotonin attenuates tumor-necrosis-factor-alpha-induced intestinal inflammation by interacting with human mucosal tissue

Veronika Bosáková, Ioanna Papatheodorou, Filip Kafka, Zuzana Tomášiková, Petros Kolovos, Marcela Hortová Kohoutková, Jan Frič

This study shows serotonin reduces inflammation in intestinal tissue by altering monocyte behavior and chemokine expression using a human 3D model.

Experimental & Molecular Medicine · Feb 2, 2025Peer-reviewedImmunology

Unveiling the guardians: IL-26-expressing MAIT cells protect epithelial barrier function and are dysregulated in Crohn's disease

Veronika Bosáková, Bo-Jun Ke, Marcela Hortová Kohoutková, Ioanna Papatheodorou, Filip Kafka, Marco De Zuani, Sneha Santhosh, Francesca Biscu, Saeed Abdurahiman, Ine De Greef, Sare Verstockt, Bram Verstockt, Séverine Vermeire, Rafael José Argüello, Gianluca Matteoli, Jan Frič

This study identifies IL-26-expressing MAIT cells as protective for epithelial barrier function and shows their dysregulation in Crohn's disease.

bioRxiv · Jun 2, 2024 · PreprintImmunology