Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex
Jeong Hyo Lee, Mo Chen, Tianmu Wen, Richard Allen Anderson, Vincent L. Cryns
This study identifies a role for nuclear phosphoinositides in regulating MDM2 stability and function through interactions with small heat shock proteins, offering a new therapeutic target in cancer.
Journal of Biological Chemistry · Jul 26, 2025Peer-reviewedCancer Biology