Weiming Yang

16S ribosomal RNA modification drives transcript-specific translation efficiency

This study shows that 16S rRNA modification by MraW enhances translation efficiency, particularly for structured mRNAs, and that mRNA stem-loops regulate protein levels through ribosome modification.

APOBEC3-driven neoantigen-rich cancers co-opt 1q23.3 amplification for tumor-intrinsic immune cloaking

The paper identifies a tumor-intrinsic immune-cloaking mechanism in neoantigen-rich cancers driven by APOBEC3 mutagenesis and 1q23.3 amplification, showing NECTIN4's role in suppressing immune responses.

Extracellular vesicles from wild-type Epstein-Barr virus-transformed B-cells export host DNA and EBV EBER1

The paper identifies extracellular vesicles (sEVs) from EBV-transformed B-cells as a vehicle for exporting host DNA and EBV EBER1 RNA, linking peripheral EBV infection to distal tissue signaling in MS.

EXoO-Tn: Tag-n-Map the Tn Antigen in the Human Proteome

The paper introduces EXoO-Tn, a method to map Tn-glycosylation sites in the human proteome, identifying 947 sites from 480 glycoproteins in Jurkat cells.

Mapping In Vivo O-Glycoproteome Using Site-specific Extraction of O-linked glycopeptides (EXoO)

The paper introduces EXoO, a method for site-specific extraction of O-linked glycopeptides, enabling the mapping of over 3,000 O-linked glycosylation sites across human tissues and revealing significant differences between tumor and normal kidney tissues.