Jason C. Mills

This study identifies IFRD1 as a ribosome-salvaging factor that stabilizes non-translating 80S ribosomes during ER stress, preventing degradation and cell death.

The paper identifies STK38 as a YAP1 kinase that regulates paligenosis by autophagy-dependent degradation, enabling differentiated cells to act as progenitors during tissue regeneration.

The paper shows that injured Drosophila gut polyploid enterocytes dedifferentiate into diploid progenitors via paligenosis, involving autophagy and TORC1.

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

This study investigates the effects of ribosome biogenesis inhibition in vivo by deleting Nat10 in mice, revealing p53-dependent and -independent consequences on acinar cell function and tumorigenesis.

This study identifies IFRD1 as a key regulator of ER stress and urothelial homeostasis in mice, showing its role in maintaining bladder function and preventing cell shedding.