Brian R. Houck-Loomis

This study tracks clonal evolution of drug resistance in ovarian cancer using structural variants in cfDNA, finding polyclonal resistance with dominant high-fitness clones and genomic features linked to drug resistance.

The paper describes the development and clinical application of MSK-ACCESS, a liquid biopsy assay that improves the specificity of somatic variant detection in cell-free DNA by using paired normal sequencing.

The paper introduces cell hashing using barcoded antibodies to enable multiplexing and doublet detection in single-cell genomics, demonstrating its effectiveness with human PBMC samples.

The paper introduces a method to simultaneously measure epitopes and transcriptomes in single cells using oligonucleotide-labeled antibodies.