Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA
Marc J. Williams, Ignacio Vázquez-Garćıa, Grittney K. Tam, Michelle Ka Yan Wu, Nancy Varice, Eliyahu Havasov, Hongyu Shi, Duaa Hassan Al-Rawi, Gryte Satas, Hannah Lees, Jake June-Koo Lee, Matthew A. Myers, Matthew Zatzman, Nicole Rusk, Emily Ali, , Sohrab P. Shah
This study tracks clonal evolution of drug resistance in ovarian cancer using structural variants in cfDNA, finding polyclonal resistance with dominant high-fitness clones and genomic features linked to drug resistance.
Nature · Oct 1, 2025Peer-reviewedCancer Biology