Author

Matthew R. Fleming

Vanderbilt University Medical CenterORCID 0000-0002-1875-7445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Dan M. RodeniD· 2 shared Megan Cummins LancasteriD· 2 shared Andrew Michael GlazeriD· 1 shared Ayesha MuhammadiD· 1 shared Björn C. KnollmanniD· 1 shared Brett M. KronckeiD· 1 shared Calum A. MacRaeiD· 1 shared Chad Daniel HuffiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Dan M. RodenORCID

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2 papers

Recent·Most cited

Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk

M. Lorena Harvey, Ellen M Osborn, Megan Cummins Lancaster, Joseh J. Smith, Qianyi Shen, Temidayo Abe, Ruoyi Cai, Ayesha Muhammad, Rose Kannankeril, Tao Yang, Maria E. Calandranis, Daniel J. Blackwell, Richard E Dolder, Jessa L. Aldridge, Matthew R. Fleming, , Andrew Michael Glazer

The paper maps the functional landscape of KCNQ1 variants to identify pathogenic and benign variants, revealing their impact on arrhythmia risk and ion channel mechanisms.

medRxiv · Dec 16, 2025 · PreprintGenetic & Genomic Medicine

Detection of distant familial relatedness in biobanks for identification of undiagnosed carriers of a Mendelian disease variant: application to Long QT Syndrome

Megan Cummins Lancaster, Hung‐Hsin Chen, Moore Benjamin Shoemaker, Matthew R. Fleming, James T. Baker, Hannah G. Polikowsky, David C. Samuels, Chad Daniel Huff, Dan M. Roden, Jennifer Elizabeth Below

This paper develops a method to identify undiagnosed carriers of a rare Mendelian disease variant by detecting distant familial relatedness in biobanks.

medRxiv · Apr 19, 2023 · PreprintGenetic & Genomic Medicine