Author

Jessa L. Aldridge

Vanderbilt University Medical CenterORCID 0000-0002-6071-9581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:electronic health records· 1

Frequent Co-Authors

Andrew Michael GlazeriD· 2 shared Chai‐Ann NgiD· 2 shared Dan M. RodeniD· 2 shared Jamie I. VandenbergiD· 2 shared Ayesha MuhammadiD· 1 shared Björn C. KnollmanniD· 1 shared Brett M. KronckeiD· 1 shared Calum A. MacRaeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Andrew Michael GlazerORCID

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2 papers

Recent·Most cited

Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk

M. Lorena Harvey, Ellen M Osborn, Megan Cummins Lancaster, Joseh J. Smith, Qianyi Shen, Temidayo Abe, Ruoyi Cai, Ayesha Muhammad, Rose Kannankeril, Tao Yang, Maria E. Calandranis, Daniel J. Blackwell, Richard E Dolder, Jessa L. Aldridge, Matthew R. Fleming, , Andrew Michael Glazer

The paper maps the functional landscape of KCNQ1 variants to identify pathogenic and benign variants, revealing their impact on arrhythmia risk and ion channel mechanisms.

medRxiv · Dec 16, 2025 · PreprintGenetic & Genomic Medicine

Cohort-scale automated patch clamp data improves variant classification and penetrance stratification for SCN5A-Brugada Syndrome

Matthew J. O’Neill, Joanne G. Ma, Jessa L. Aldridge, Joseph F. Solus, Genevieve R Harvey, Paige H Roberson, Julien Barc, Connie R. Bezzina, Dan M. Roden, Roddy Walsh, Jamie I. Vandenberg, Andrew Michael Glazer, Chai‐Ann Ng

The paper uses automated patch clamp data to reclassify SCN5A variants in Brugada Syndrome, improving variant classification and penetrance stratification.

European Heart Journal · Nov 18, 2025Peer-reviewedGenetic & Genomic Medicine