Cancer BiologybioRxivPreprint
Enhanced BCMA Antigen Density Increases Trogocytosis and Attenuates CAR T cell Function
Pınar Ataca Atilla, Sylvain Simon, Erden Atilla…·Damian J. Green
This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.