David Glen Coffey

This study uses SCID-rab PDX models to analyze genomic and transcriptomic features of multiple myeloma, revealing selection of pre-existing high-risk clones.

This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.

The paper identifies KSHV-specific T-cell receptors in KS tumors, showing they recognize lytic KSHV gene products and could inform immunotherapies.

Fate-AI improves cancer detection sensitivity and generalization by integrating fragmentomic and methylation features from cfDNA sequencing.

The paper identifies KSHV- and HIV-specific T-cells in KS tumors and shows they persist over time and coexist with immunosuppressive macrophages.

This study identifies genomic and immune factors associated with resistance to anti-CD38 therapy in multiple myeloma patients.