Carolyn Shasha

This study shows human CD4 T cells can drive antitumor immunity in MHC class II-negative cancers through indirect antigen presentation via APCs.

This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.

This study identifies a pro-inflammatory role of Granzyme K-producing bystander CD8+ T cells in AML, which promote IL-8 secretion and may exacerbate disease progression.

The paper shows that B cells specific for viral oncoproteins in Merkel cell carcinoma tumors predict long-term disease control and enhance T cell responses.

The paper profiles CD8+ T cells in multiple myeloma patients to assess tumor reactivity and exhaustion, finding no evidence of tumor-experienced T cells with hallmark exhaustion or activation features.

Superscan is a supervised machine learning model for single-cell RNA-seq cell type annotation, showing improved accuracy and speed over existing methods.