Sylvain Simon

This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.

The paper identifies CD163+ monocytes and immature CD177+ neutrophils as markers of severe neurotoxicity after CD19 CAR T cell therapy through multi-omics profiling.

This study shows that varying CAR expression levels in T cells affects their activation, function, and transcriptional identity, with optimal CAR levels preventing exhaustion.