Author

Yichong Lao

University of Wisconsin–MadisonORCID 0000-0002-1895-1467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chen Shi· 1 shared Cheng-Guo WuiD· 1 shared Haidai HuiD· 1 shared Jiancheng LuoiD· 1 shared Michael S. O’ConnoriD· 1 shared Nicholas M. I. TayloriD· 1 shared Peng XiuiD· 1 shared Xuhui HuangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Chen Shi

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2 papers

Recent·Most cited

BiophysicsJournal of the American Chemical SocietyPeer-reviewedSep 24, 2026

Asymmetric Hydration and Protonation Switching of Dual Aspartates Drive Flagellar Rotation

Jiancheng Luo, Haidai Hu, Zhitao Cai…·Yong Wang

This study investigates the rotational mechanism of the bacterial flagellar motor by analyzing protonation dynamics and structural asymmetry in CjMotAB using cryo-EM and computational methods.

DOI 10.1021/jacs.6c07910

bacteria (other)cryo-EM

𝕏 PostBluesky

BiophysicsbioRxivPreprintAug 23, 2026

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

Michael S. O’Connor, Cheng-Guo Wu, Yichong Lao…·Xuhui Huang

This paper investigates the activation mechanism of PP2A-B56δ by analyzing disease variant E198K using cryo-EM and computational methods, revealing progressive loosening of the N/C-arm interface as the activation pathway.

DOI 10.64898/2026.08.19.745767

cryo-EMdeep learning

𝕏 PostBluesky