Nicholas M. I. Taylor

This study investigates the rotational mechanism of the bacterial flagellar motor by analyzing protonation dynamics and structural asymmetry in CjMotAB using cryo-EM and computational methods.

This study uses cryo-EM and tomography to reveal the structural changes in bacteriophage P2 during tail contraction and host infection, identifying new architectural features and mechanisms of genome translocation.

This study resolves the structure of bacteriophage T4 at different stages, revealing mechanisms of genome delivery and superinfection exclusion.

This study identifies structural modularity in Klebsiella pneumoniae phage RBPs, showing how modular exchange drives host-range diversification across multiple scales.

This study investigates the molecular mechanism of the Druantia anti-phage defense system, showing that DruH-E provides robust immunity and revealing its DNA unwinding and regulation by ATP.

The paper reports the structure of a novel contractile injection system in Salmonella enterica subsp. salamae and identifies a new CIS cluster.

The paper defines a global map of receptor-binding protein compatibility for designing phages targeting Klebsiella and Acinetobacter species.

This study presents the cryo-EM structures of PlPVC1 in extended and contracted states, revealing structural features and contraction mechanism insights.

This paper introduces RBPseg, a method to predict high-confidence tail fiber structures using segmentation and deep learning, and validates it with experimental data and structural classification.

This study uses MD simulations to show that N99 glycosylation in ATG9A enhances protomer interactions and lipid scrambling, but does not significantly affect autophagy flux.

This study determines the structure of Rhs core domains from T6SS proteins and suggests their dual role in toxin delivery and self-protection.

This study reveals the structure and mechanism of the Zorya anti-phage defense system using cryo-EM and functional assays, showing how it detects phage invasion and activates defense.

This study identifies an N-terminal signal peptide that enables efficient loading of therapeutics into the Afp nano-injection system for targeted delivery.

This study reports cryo-EM structures of MRP4 with various substrates, revealing molecular details of its transport mechanism and broad substrate specificity.

The paper reports two new polymorphic structures of alpha-synuclein fibrils solved by cryo-EM, showing distinct structural features and interactions compared to previous structures.

The paper reports the cryo-EM structure of alpha-synuclein fibrils, revealing key features relevant to disease mechanisms and therapeutic design.