Cheng-Guo Wu

This paper introduces cryoSHIELDs, tunable peptides that improve cryo-EM sample preparation by modulating the air-water interface, enhancing particle distribution and complex integrity across multiple protein systems.

This paper investigates the activation mechanism of PP2A-B56δ by analyzing disease variant E198K using cryo-EM and computational methods, revealing progressive loosening of the N/C-arm interface as the activation pathway.

This study uses library docking to identify subtype-selective CB2 receptor ligands, finding improved hit rates and affinities with larger libraries and structure-based optimization.

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.