Xuhui Huang

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

This paper investigates the activation mechanism of PP2A-B56δ by analyzing disease variant E198K using cryo-EM and computational methods, revealing progressive loosening of the N/C-arm interface as the activation pathway.

Nucleosome condensate and linker DNA alter chromatin folding pathways and rates

This study maps chromatin folding pathways and rates using a coarse-grained model, showing that linker DNA length and nucleosome condensate affect stability and structure.

Human Replication Protein A complex is a Telomerase Processivity Factor Essential for Telomere Maintenance

This study identifies RPA as a telomerase processivity factor essential for telomere maintenance and shows its role in telomere-related diseases.

ChemPLAN-Net: A deep learning framework to find novel inhibitor fragments for proteins

ChemPLAN-Net uses deep learning to predict novel inhibitor fragments for proteins by analyzing physicochemical features and co-crystal structures.

Allosteric effector ppGpp potentiates the inhibition of transcript initiation by DksA

This study reports the X-ray crystal structures of E. coli RNA polymerase complexes with DksA and ppGpp, revealing how ppGpp enhances DksA's inhibition of transcription initiation.