Tunable 3D Alveolosphere Model from Human Alveolar Cells: A Breakthrough Tool to Explore Emphysema Pathophysiology
Marina Guecamburu, Arthur Pavot, Caroline Jeannière, Yaniss Belaroussi, Matthieu Thumerel, Emma Samaniego, Hugues Bégueret, Guillaume Maucort, Fanny Decoeur, Jean‐William Dupuy, Anne‐Aurélie Raymond, Pauline Estèves, L. Grassion, Gaël Dournes, Patrick Berger, , M. Zysman
The paper develops a tunable 3D-alveolosphere model from human primary AEC2 cells to study emphysema, showing key native alveolar features and pathophysiological responses to cigarette smoke extract.
bioRxiv · Apr 9, 2025 · PreprintCell Biology