Jean‐William Dupuy

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer, a novel cancer-relevant paralog interplay

This study identifies a novel paralog interplay between p190A and p190B in endometrial cancer, showing synthetic lethality and actin remodeling effects upon their removal.

Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions

This study identifies glycerol as a trigger for Trypanosoma brucei differentiation into transmissible forms under tissue-like conditions, challenging the traditional bloodstream model of transmission.

LRP-1 promotes tumor progression of triple negative breast cancers by coordinating extracellular matrix remodeling and immune cell infiltration

This study shows LRP-1 promotes TNBC progression by remodeling the extracellular matrix and reducing immune cell infiltration.

Role of the clathrin adaptor AP-1 in cell wall integrity and virulence factor secretion in the plant pathogen Botrytis cinerea

This study investigates the role of AP-1 clathrin adaptor complex in vesicle trafficking, cell wall integrity, and virulence in Botrytis cinerea, finding defects in secretion and pathogenicity in an AP-1 mutant.

Src promotes tumor cell invasion by hijacking the translation machinery

This study shows Src promotes tumor cell invasion by regulating mRNA translation through eIF3 subunits, essential for invadosome formation and ECM degradation.

Standardized brain and plasma EV enrichment pipeline validated for Single sample multi-Omic and fatty acids applications in Mouse and Human

The paper presents a standardized workflow for multi-omic profiling of brain and plasma-derived EVs from minimal human and mouse material, revealing tissue-specific and species-specific molecular signatures.

Proteomic profiling of advanced hepatocellular carcinoma identifies predictive signatures of response to treatments

This study identifies proteomic signatures predictive of treatment response in advanced hepatocellular carcinoma using mass spectrometry and machine learning.

Tks5 interactome reveals ER-associated machinery translation in invadosomes.

The paper identifies ER-associated translation machinery in invadosomes using Tks5 interactome analysis, revealing its role in invadosome formation and function.

Tunable 3D Alveolosphere Model from Human Alveolar Cells: A Breakthrough Tool to Explore Emphysema Pathophysiology

The paper develops a tunable 3D-alveolosphere model from human primary AEC2 cells to study emphysema, showing key native alveolar features and pathophysiological responses to cigarette smoke extract.

Cancer cells transfer invasive properties through microRNAs contained in collagen-tracks

The paper identifies collagen-tracks as a new form of cell-cell communication that transfer invasive properties via miRNAs, promoting metastasis in breast cancer.

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

The paper identifies ZMYND12 as a gene associated with male infertility and flagellum function through genetic and functional studies in humans and Trypanosoma brucei.