Mark M. Emerson

This study shows the Nrl promoter is active in both rod and cone photoreceptors, challenging its use as a rod-specific marker and suggesting flaws in current gene regulatory network models.

The paper investigates the development of the little skate retina, identifying a novel onecut1 isoform and its potential regulatory role in photoreceptor development.

This study enhances plasmid-based transcriptional activation in developing mouse photoreceptors by using optimized cis-regulatory elements from the Crx gene.

This study identifies the role of Notch signaling in repressing cone photoreceptor formation by maintaining multipotent retinal progenitor cells and preventing their transition to restricted progenitor cells.

This study identifies cis-regulatory elements that regulate horizontal cell development by analyzing enhancer activity and transcription factor interactions.

The paper identifies cis-regulatory elements near Onecut1 that control fate-restricted retinal progenitor cell development through bHLH transcription factor interactions.

The paper identifies genes enriched in early developing mouse cone photoreceptors using single-cell RNA sequencing and compares them to existing datasets.

The paper develops a lineage tracing system in chicken embryos to characterize the progeny of ThrbCRM1-expressing retinal progenitor cells, finding they generate cone photoreceptors, horizontal cells, and specific retinal ganglion cell subtypes.

This study uses CRISPR/Cas9 to disrupt OTX2 in retinal progenitors, revealing its role in suppressing alternative cell fates and maintaining proliferative potential.

The paper systematically varies transcriptional reporter plasmid levels, trans-acting factors, and binding sites to analyze properties of a retinal enhancer during development.