BiochemistryCell ReportsPeer-reviewed
HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
Takayuki Ikeda, Sungki Hong, Shota Yoshida…·Ken Inoki
This study shows HUWE1 enhances mTORC1 activity by promoting Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis via CAD activation.