Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
Bing Wang, Vladimir V. Svetlov, Yuri I. Wolf, Eugene V. Koonin, Evgeny Nudler, Irina Artsimovitch
The paper investigates how phosphorylated nucleotides like remdesivir triphosphate and ppGpp activate SARS-CoV-2 RdRp through allosteric mechanisms involving the NiRAN domain and Nsp7/8 subunits.
bioRxiv · Jan 24, 2021 · PreprintMolecular Biology