Bing Wang

The paper investigates how RfaH and NusG regulate RNA polymerase pausing during transcription of long operons in E. coli, showing RfaH extends transcription runs and compensates for NusA's pause-inducing effect.

The paper shows that Sfx, a histone-like protein in R6K plasmid, selectively silences the vir operon by forming stable nucleoprotein filaments and phase separating with plasmid DNA.

The paper predicts RfaH homolog structures using AlphaFold2, identifies active-state homologs, and supports a stepwise evolutionary model of RfaH specialization.

This study shows that coronavirus polymerase template switching is driven by nsp13-helicase and is enhanced by remdesivir and molnupiravir, leading to defective RNA production.

The paper investigates how phosphorylated nucleotides like remdesivir triphosphate and ppGpp activate SARS-CoV-2 RdRp through allosteric mechanisms involving the NiRAN domain and Nsp7/8 subunits.