A Single Chimeric Spike Antigen Induces Pan-Sarbecovirus Immunity
Claudio Counoupas, Elizabeth Chan, Paco Pino, Joshua Armitano, Matt D. Johansen, Lachlan J. Smith, Caroline L. Ashley, Eva Estapé, Jean Troyon, Sibel Alca, Stefan Miemczyk, Nicole G. Hansbro, Gabriella M. Scandurra, Warwick J. Britton, Thomas Courant, , James A. Triccas
This study develops a chimeric spike antigen vaccine (CoVEXS5) that induces broad immunity against multiple SARS-CoV-2 variants and other sarbecoviruses in animal models.
npj Vaccines · May 8, 2025Peer-reviewedImmunology