Developmental BiologybioRxivPreprint
Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells.
Thulaj Meharwade, Loïck Joumier, Maxime Parisotto…·Mohan K. Malleshaiah
This study identifies BMP4 as an inducer of the Totipotent state in mouse ESCs, showing that its effect is constrained by cross-activation of FGF, TGF-β, and WNT pathways, and demonstrates that inhibiting these pathways increases Totipotent cell proportion.
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