Loïck Joumier

BMP and NODAL Paracrine Signalling Regulate the Totipotent-like Cell State in Embryonic Stem Cells.

This study identifies BMP and NODAL signalling as critical for regulating totipotent-like cell states in embryonic stem cells through cell-cell communication.

Induction of cellular totipotency by NACC1-driven feed-forward regulation.

The paper identifies NACC1 as a regulator of totipotent-like cells in mouse embryonic stem cells through a feed-forward mechanism involving gene regulation and retrotransposon activity.

Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells.

This study identifies BMP4 as an inducer of the Totipotent state in mouse ESCs, showing that its effect is constrained by cross-activation of FGF, TGF-β, and WNT pathways, and demonstrates that inhibiting these pathways increases Totipotent cell proportion.