Mohan K. Malleshaiah

The paper identifies a negative feedback loop between lncRNA FENDRR and FOXF1 that regulates protein levels during fibroblast-to-myofibroblast transition in lung development.

This study identifies BMP and NODAL signalling as critical for regulating totipotent-like cell states in embryonic stem cells through cell-cell communication.

The paper identifies NACC1 as a regulator of totipotent-like cells in mouse embryonic stem cells through a feed-forward mechanism involving gene regulation and retrotransposon activity.

This study identifies BMP4 as an inducer of the Totipotent state in mouse ESCs, showing that its effect is constrained by cross-activation of FGF, TGF-β, and WNT pathways, and demonstrates that inhibiting these pathways increases Totipotent cell proportion.