Edroaldo Lummertz da Rocha

This paper identifies a CD107a+ macrophage subset with enhanced phagocytic ability for mycobacteria and shows its role in tuberculosis defense.

The paper identifies positive feedback loops between Lin28-RBPs and mRNAs that regulate spatiotemporal transitions of progenitors during organogenesis.

This study identifies two distinct macrophage differentiation pathways in humans, showing how developmental origin influences macrophage function and identifies a method to expand tissue-resident macrophages.

This study identifies Erg as a master transcription factor whose upregulation during aging is critical for adult hematopoietic stem cell function and resistance to leukemogenesis.

This study identifies BMP4 as an inducer of the Totipotent state in mouse ESCs, showing that its effect is constrained by cross-activation of FGF, TGF-β, and WNT pathways, and demonstrates that inhibiting these pathways increases Totipotent cell proportion.

The paper identifies a Lin28b-let-7-PRC1 axis that regulates hematopoietic maturation across development, with Cbx2 playing a key role in controlling developmental timing of hematopoietic transcription factors.

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

The paper uses single cell RNA-seq to study human hematopoietic stem and progenitor cells (HSPCs) across development and aging, revealing age-related transcriptional changes and differentiation trajectories.

The paper evaluates the transcriptional fidelity of cancer models using a machine learning tool called CancerCellNet, finding that genetically engineered mice and tumoroids generally show higher fidelity than other model types.