Deep Learning-based Modeling Enhances Efficacy of Natural Ligand CAR Binders Targeting CD70
Amrik S. Kang, Radhika Dalal, Mingcheng Li, Anupam Anand Ojha, Sujata B. Walunj, Caitlin E. Cornell, Ruyan Rahnama, Abhilash Barpanda, Sanjana Prudhvi, Trishna S. Patel, Mark Aspinall-O’Dea, Beth Walker, Clare Adams, Veronica Steri, Paul J. Phojanakong, , Arun P. Wiita
This study uses deep learning and physics-based modeling to engineer a CD27 variant that improves the efficacy of CD70-targeting CAR T-cells across multiple cancer models.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology