Ashir A. Borah

This paper aligns a protein generative model with experimental fitness using Direct Preference Optimization, improving stability prediction and enabling new applications.

The paper identifies RNF8 and MIS18A as chromatin organizers that modulate intratumoral heterogeneity in breast cancer, affecting therapeutic sensitivity and metastasis.

The paper identifies a metastasis-suppressive regulatory axis involving RBMS3 and TXNIP by analyzing mRNA stability in breast cancer using a deep-learning framework.

This study shows that p53 activity persists in HPV+ HNSCC tumors with WT TP53, leading to better survival and therapeutic vulnerabilities.

This study uses in vivo perturb-seq to analyze gene function and radiotherapy responses in glioblastoma by targeting cancer and microenvironment cells.

The paper identifies 245 putative RNA structural switches in the human transcriptome using a computational and experimental approach, validates one with DMS-MaPseq and cryo-EM, and shows its regulation by trans factors and nonsense-mediated decay.