Bioengineered bone marrows that can support stem cells and remodel to mimic human disease metabolism and chemotherapeutic effects
Yinbo Xiao, Savvas Ioannou, Monica P. Tsimbouri, Xiang Li, Oana Dobre, Sara Trujillo, Mark Robert Sprott, Mariana Azevedo Gonzalez‐Oliva, Vineetha Jayawarna, Massimo Vassalli, Ewan A. Ross, Mhairi Copland, Peter S. Young, Dominic R. M. Meek, Manuel Salmerón‐Sánchez, , Matthew John Dalby
The paper develops a bioengineered bone marrow model that supports stem cells and mimics disease metabolism and chemotherapy effects, showing enhanced taurine metabolism and chemotherapy response.
bioRxiv · Dec 5, 2025 · PreprintBioengineering